TABLE 1.

Main contributions of Rab RE-associated with neuronal development.

RE-resident	Endosomal
Rab/Ras	localization	Main contribution to neuronal development	Experimental model	References
Rab4	EE, RE	Promotes axon elongation.	Xenopus laevis	Falk et al., 2014
		Critical for maintaining dendritic spine size.	Rat hippocampal neurons	Brown et al., 2007; Hoogenraad et al., 2010
		Regulates synapse homeostasis through kinesin-2 mediated trafficking.	Drosophila	Dey et al., 2017
Rab8	TGN, RE	Involved in the transport of proteins to the dendritic surface and in neurite outgrowth.	Rat hippocampal neurons	Huber et al., 1993, 1995
		Required for the local delivery of AMPARs into synapses.	Rat hippocampal neurons	Gerges et al., 2004
		Regulates axonal outgrowth via GRAB-mediated Rab8-Rab11 cascade in a Cdk5-dependent manner.	Mouse cortical neurons	Furusawa et al., 2017
Rab11	RE	Promotes neurite/axonal elongation and axon regeneration.	Rat cortical neurons	Takano et al., 2012; Koseki et al., 2017;
		Promotes AMPARs and PSD-95 clusters at the synapses along actin and microtubule cytoskeleton.	Rat hippocampal neurons	Esteves da Silva et al., 2015
		Involved in dendritic branching and spatial memory formation.	Rat hippocampal neurons	Siri et al., 2020
		Participates in N-Cadherin trafficking regulating neuronal migration and maturation.	Mouse cerebral cortex	Kawauchi et al., 2010
		Required for actin cytoskeleton remodeling during early Drosophila furrow formation.	Drosophila	Riggs et al., 2003
		Required for the development of the outer segment of rod cell membranes.	Mouse retina cells	Reish et al., 2014
		Involved in Zebrafish embryonic differentiation and development of the nervous system.	Zebrafish	Zhang et al., 2019
Rab13	TGN, RE	Increases neurite outgrowth.	PC12; Mouse dorsal root ganglion neurons	Di Giovanni et al., 2005; Kobayashi et al., 2014
		Involved in the reorganization of the actin cytoskeleton through the Rab13-JRAB/MICAL-L2 interaction.	PC12	Sakane et al., 2010
Rab17	EE, RE	Regulates dendrite morphogenesis and postsynaptic development.	Mouse hippocampal neurons	Mori et al., 2012, 2013
		Regulates dendritic surface insertion of GluK2-containing KARs by dendritic trafficking of Syntaxin-4.	Rat hippocampal neurons; Neuro2A	Mori et al., 2014
Rab35	RE	Promotes neurite outgrowth.	PC12; N1E-115	Chevallier et al., 2009; Kobayashi and Fukuda, 2013
		Regulates membrane trafficking from recycling endosomes to neurite tips during neurite outgrowth.	PC12	Kobayashi et al., 2014
		Regulates axonal elongation and Cdc42 activity in neurons.	Rat hippocampal neurons	Villarroel-Campos et al., 2016b
		Implicated on sorting of synaptic vesicle proteins in neuromuscular junctions.	Drosophila	Uytterhoeven et al., 2011
		Involved in maintain axonal integrity via UNC-70/β-spectrin-TBC10-Rab35.	Caenorhabditis elegans	Coakley et al., 2020
Arf6	RE	Inhibits neurite/dendritic/axonal elongation and branching during neuronal development.	PC12; Chick retinal and rat hippocampal neurons; Aplysia motor neurons	Hernandez-Deviez et al., 2002, 2004; Albertinazzi et al., 2003; Huh et al., 2003; Kobayashi and Fukuda, 2012
		Enhances clathrin/AP-2 recruitment at the synapse by PIPKIγ activation.	Rat cortical neurons	Krauss et al., 2003
		Regulates the formation and maintenance of the dendritic spines.	Rat hippocampal neurons	Miyazaki et al., 2005; Choi et al., 2006; Kim et al., 2015
		Regulates neuronal migration in the developing cerebral cortex.	Mouse cerebral cortex	Arvanitis et al., 2013; Falace et al., 2014
		Promote neurotransmitter release at the neuromuscular junction.	Xenopus laevis	Ashery et al., 1999
		Regulates traffic pathways during photoreceptor development.	Zebrafish	George et al., 2016

The table summarizes the role of RE-resident Rabs/Ras reported in processes mainly associated with neuronal differentiation and migration of several experimental models.