Table 1.

List of DDR-KSHV interaction during de novo infection, latency, and lytic reactivation and its effects.

	Cellular DDR proteins	Viral components	Effects	Refs.
De novo infection	γH2AX	LANA	Episome persistence	Jha et al., 2013
	γH2AX, ATM	?	Establishment of latency	Singh et al., 2014
Latent	PARP1	TR, LANA	Negative for virus maintenance	Ohsaki et al., 2004
	ATM, Chk2, γH2AX, p53	v-cyclin	Oncogenic	Koopal et al., 2007
	DNA-PK, Ku70/80	LANA	Negative for virus maintenance	Cha et al., 2010
	Chk2	LANA	Protection from G2/M cell cycle arrest	Kumar et al., 2014
	GADD45B	miRNA-K9	Anti-apoptotic, Protection from cell cycle arrest	Liu et al., 2017
	MRN	cytoplasmic LANA (LANA⊿N)	Modulation of an innate immune signaling pathway	Mariggiò et al., 2017
Lytic	PARP1	RTA	Abortive lytic replication	Gwack et al., 2003
	ATM, p53	vIRF1	Downregulation of DDR for viral replication	Shin et al., 2006
	PARP1	ori-Lyt	Positive for lytic DNA replication	Wang et al., 2008
	Ku70/80, DNA-PK, MSH2/6	ori-Lyt	Supportive for lytic DNA replication	Wang et al., 2008
	TIP60	ORF36	Positive for lytic gene expression	Li et al., 2011
	γH2AX, Mre11, Rad50, Ku70/80, DNA-PK, PARP1, XRCC1, DNA ligase 3	ORF57	Genomic instability	Jackson et al., 2014
	RPA, Mre11	lytic replication foci	Positive for viral DNA synthesis	Hollingworth et al., 2015
	DNA-PK, Ku80	lytic replication compartments	Negative for viral DNA replication	Hollingworth et al., 2017
	MRN	lytic replication compartments	Positive for viral DNA replication	Hollingworth et al., 2017