Figure 4.

Gut-tropic plasma cells correlated with serum titres of Vi-IgA. (A) Serum Vi-IgA titres were measured pre- and post-vaccination. Titres are represented on a Log2 scale. Each dot represents one participant At baseline in the Vi-TT group, n = 33. At 7 days post-vaccination, n = 36. At baseline in the Vi-PS group, n = 37. At seven days post-vaccination, n = 37. Significance was determined via a Wilcoxons signed paired rank test (two-tailed). ***p< 0.001, ****p < 0.0001, ns, not significant. (B) The frequency of CCR10+ IgA+ plasma cells 7 days after vaccination were correlated with logged Vi-IgA titres 1 month after vaccination using a Spearman’s correlation. In the Vi-PS group, n = 20. In the Vi-TT group, n = 19.