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. 2020 Dec 2;11:608492. doi: 10.3389/fimmu.2020.608492

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Copyright © 2020 Merli, Algeri, Gaspari and Locatelli

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mechanism of action of emapalumab. The drug binds to both free and receptor-bound IFNγ, inhibiting both receptor dimerization and signal transduction via JAK-STAT pathway.