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. 2020 Nov 30;10:600322. doi: 10.3389/fonc.2020.600322

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Copyright © 2020 Zhao, Hao, Zhao, Jiang and Zheng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The bioinformatics analysis of Dkk3 mRNA expression in colorectal cancer. Oncomine (A) and TCGA (B) data sets were employed to analyze Dkk3 expression in colorectal cancer, and its expression was compared with pathological parameters of cancers. Dkk3 mRNA expression was higher in cancer-associated fibroblasts (CAF) than CD133-positive (CD133+) and -negative (CD133-) colorectal cancer cells (C). Kaplan-Meier curves were used to analyze the prognostic significance of Dkk3 mRNA expression according to KM plotters (D). HR, hazard ratio; N, lymph node metastasis. *p < 0.05; ****p < 0.001.