FIGURE 2.

Function of WNT6. In the mouse embryo, WNT6 is expressed and promote stromal cell proliferation during decidualization and induces pre-tubular aggregation in the mesenchyme during formation of the renal tubule. WNT6 also prevents adipogenesis and stimulates osteoblastogenesis in mice. With respect to disease, in mice, loss of WNT6 correlates with the development of kidney fibrosis, and WNT6 can maintain the integrity of epithelium. WNT6 expression promotes the development of lung tuberculosis and GBM. In human cell models, WNT6 expression promotes the differentiation and migration of hDPCs and promotes the formation and development of tumors.