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The molecular basis of selected cell death programs. Illustration of key events in apoptosis (A), necroptosis (B), pyroptosis (C) and lysosome-dependent cell death (D). The representations are simplified. Cross-talks between pathways and links to inflammatory signaling are not depicted. Moreover, in (B), the signaling events between the receptors and the effectors of necroptosis are not shown. RIPK1 is dispensable for some modes of necroptosis.
