Table 1.
Demographics of study participants by FAQ group
| Variable | FAQ=0 N= 4421 | FAQ≥1 N= 973 | Total N= 5394 | p |
|---|---|---|---|---|
| Age, years | <0.00011 | |||
| Mean (SD) | 71.9 (9.9) | 79.1 (7.8) | 73.2 (9.9) | |
| Median (IQR) | 73.0 (64.6, 79.3) | 80.7 (74.8, 84.4) | 74.2 (66.4, 81.1) | |
| Male sex, N (%) | 2201 (49.8) | 528 (54.3) | 2729 (50.6) | 0.01142 |
| Education, yearsa | <0.00011 | |||
| Mean (SD) | 14.4 (2.7) | 13.7 (3.0) | 14.3 (2.8) | |
| Median (IQR) | 14.0 (12.0, 16.0) | 13.0 (12.0, 16.0) | 14.0 (12.0, 16.0) | |
| MCI, N (%) | 336 (7.6) | 342 (35.1) | 678 (12.6) | <0.00012 |
| Charlson indexb | <0.00011 | |||
| Mean (SD) | 2.9 (2.9) | 4.4 (3.5) | 3.1 (3.1) | |
| Median (IQR) | 2.0 (1.0, 4.0) | 4.0 (2.0, 6.0) | 2.0 (1.0, 4.0) | |
| Psychotropic medication, N (%) | 735 (16.6) | 209 (21.5) | 944 (17.5) | 0.00032 |
| Hypertension, N (%)c | 2850 (64.9) | 793 (81.8) | 3643 (68.0) | <0.00012 |
| Diabetes, N (%)c | 723 (16.5) | 226 (23.3) | 949 (17.7) | <0.00012 |
| Dyslipidemia, N (%)c | 3501 (79.8) | 803 (82.8) | 4304 (80.3) | 0.03352 |
| Smoking ever, N (%) | 2060 (46.6) | 467 (48.0) | 2527 (46.8) | 0.42822 |
| FAQ total score | <0.011 | |||
| Mean (SD) | 0.0 (0.0) | 3.1 (3.6) | 0.6 (2.0) | |
| Median (IQR) | 0.0 (0.0, 0.0) | 2.0 (1.0, 4.0) | 0.0 (0.0, 0.0) | |
| Delusions, N (%)d | 3 (0.1) | 24 (2.6) | 27 (0.6) | <0.00012 |
| Hallucinations, N (%)d | 1 (0.0) | 12 (1.3) | 13 (0.3) | <0.00013 |
| Agitation, N (%)d | 76 (1.9) | 81 (8.9) | 157 (3.2) | <0.00012 |
| Depression, N (%)d | 374 (9.4) | 238 (26.1) | 612 (12.5) | <0.00012 |
| Anxiety, N (%)d | 203 (5.1) | 128 (14.0) | 331 (6.8) | <0.00012 |
| Euphoria, N (%)d | 10 (0.3) | 19 (2.1) | 29 (0.6) | <0.00012 |
| Apathy, N (%)d | 128 (3.2) | 155 (17.0) | 283 (5.8) | <0.00012 |
| Disinhibition, N (%)d | 24 (0.6) | 52 (5.7) | 76 (1.6) | <0.00012 |
| Irritability, N (%)d | 259 (6.5) | 189 (20.7) | 448 (9.1) | <0.00012 |
| Motor behavior, N (%)d | 19 (0.5) | 22 (2.4) | 41 (0.8) | <0.00012 |
| Nighttime behavior, N (%)e | 189 (5.6) | 179 (22.4) | 368 (8.8) | <0.00012 |
| Appetite change, N (%)d | 129 (3.2) | 112 (12.3) | 241 (4.9) | <0.00012 |
| BDI-II scoref | <0.00011 | |||
| Mean (SD) | 4.5 (4.6) | 6.8 (6.2) | 4.9 (5.0) | |
| Median (IQR) | 3.0 (1.0, 7.0) | 5.0 (2.0, 9.0) | 4.0 (1.0, 7.0) | |
| BDI-II score≥13, N (%)f. | 271 (6.2) | 144 (15.3) | 415 (7.8) | <0.00012 |
| BAI scoreg | <0.00011 | |||
| Mean (SD) | 2.7 (4.1) | 4.1 (5.4) | 3.0 (4.4) | |
| Median (IQR) | 1.0 (0.0, 4.0) | 2.0 (0.0, 6.0) | 1.0 (0.0, 4.0) | |
| BAI score≥10, N (%)g | 272 (6.2) | 120 (12.4) | 392 (7.3) | <0.00012 |
FAQ, Functional Activities Questionnaire; SD, standard deviation; IQR, interquartile range; BDI-II, Beck Depression Inventory-II; BAI, Beck Anxiety Inventory.
a
Information missing on 5 participants
b
Information missing on 1 participant
c
Information missing on 36 participants
d
Information missing on 491 participants
e
Information missing on 1199 participants
f
Information missing on 102 participants
g
Information missing on 12 participants. p-value based on
1
Kruskal-Wallis test
2
Chi-square test
3
Fisher Exact test.