Table 3.
The effect of UV on coronavirus.
| Virus | Waves | Intensity of UV | Notes | Reference | |
|---|---|---|---|---|---|
| SARS-CoV-2 | MOI 0.05 | 254 nm | 3.7 mJ/cm2 | SARS-CoV-2 replication was completely inactivated at UV-C dose of 3.7 mJ/cm2 after 6 days | Bianco et al. (2020) |
| MOI 5 | 3.7 mJ/cm2 | The UV-C dose of 3.7 mJ/cm2 was effective in a reduction of viral replication (3 log reduction after 24 h). | |||
| MOI 1000 | 16.9 mJ/cm2 | Viral replication was totally inactivated at a dose 16.9 mJ/cm2. | |||
| SARS-CoV | BSC's UV lamp |
134 μW/cm2 | After 15min UV exposure, the titer of virus went down to 1.8 × 102 TCID50/mL (initial titer was 3.8 × 107 TCID50/mL). But, the virus was not completely inactivated (18.8 TCID50/mL), even after 60min of irradiation. |
Kariwa, Fujii, and Takashima (2006) | |
| SARS-CoV strain P9 | 260 nm | >90 μW/cm2 | After 15 min UV exposure, the CPE of SARS-CoV was reduced from 51 to 75% to less than 25% and dropped to an undetectable level after 60 min irradiation. | Duan et al. (2003) | |
| SARS-CoV | 365 nm (UV-A) | 2133 μW/cm2 | For more than 15min, UV-A exposure didn't have significant effects on virus inactivation. | Darnell., 2004 | |
| 254 nm (UV-C) | 4016 μW/cm2 | UV-C exposure to virus showed increasing efficiency up to 6min (resulting in a 400-fold decrease in infectious virus). And there was no additional inactivation from 6 to 1 min. |
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| MOI 0.05: Low-level concentration observed in closed environments (e.g. hospital rooms) MOI 5: Intermediate-level concentration corresponds to the average concentration found in the sputum of COVID-19 infected patients MOI 1000: High-level concentration corresponds to that observed in terminally diseased COVID-19 patients BSC's UV lamp: Biosafety Cabinet's UV lamp (typically 254 nm) | |||||