Table 1.

Patients characteristics during reference and observation period

	Reference period	Observation period	p value
Appendicitis per 1 million insurance holders/month	116 ± 8.5	101 ± 8.9	0.0091
Female (%)	56.0%	53,6%	n.s.
Appendectomies per 1 million insurance holders/month	106 ± 8.0	92 ± 7.0	0.0077
Age < 40	60.4%	58.6%	n.s.
Age 40–60	23.3	23.7
Age 60–80	13.6	14.8
> 80	2.6	2.8
Average age (in years)	38.59 ± 0.9	39.91 ± 0.4	< 0.0001
At least one comorbidity (%)	26.0% ± 1.7	28.8% ± 1.0	0.0082
Obesity (%)	5.7% ± 0.8	6.3% ± 0.5	n.s.
Cardiac disease (%)	8.6% ± 1.1	9.6% ± 1.3	n.s.
Diabetes (%)	3.9% ± 1.3	4.5% ± 0.9	n.s.
Hypertension (%)	17.9% ± 1.3	20.1% ± 1.0	0.0083
Chronic kidney disease (%)	8.7% ±  1.2	9.7% ±  0.5	n.s.