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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Hum Mutat. 2020 Jul 15;41(10):1751–1760. doi: 10.1002/humu.24078

Figure 3.

Figure 3.

a-c) The number of reported silent mutations in 16 possible trinucleotides with “C” in the middle for different categories of genes. d-f) The number of sites of silent mutations in 16 possible trinucleotides with “C” in the middle for different categories of genes. g) The numbers of silent mutations per site across trinucleotides across different gene categories. h-i) Relative mutation densities in all COSMIC-defined cancer genes (h) and melanoma genes (i). For melanoma genes we separately analyzed non UV-induced (light bars) and UV-induced (dark bars) C>T substitutions producing silent mutations. Horizontal lines shows averages for non UV-induced (light gray) and UV-induced (dark gray) silent mutations.