Table 1.

Partitioning of genome wide screen detected somatic mutations in cutaneous melanoma by known mutational signatures.

Signature	Proposed Etiology	% of mutations
7	UV light	0.764
23	Unknown (liver cancer)	0.069
1	Age	0.062
10	POLE (ultra-hypermutation)	0.034
11	Alkylating agents	0.022
12	Unknown (liver cancer)	0.01
17	Unknown (different cancers)	0.009
2	APOBEC	0.008
21	Unknown (stomach cancer / MSI)	0.007
4	Smoking	0.006
3	BRCA1 / BRCA2 (failure of DNA DSBR / large INDELs)	0.005
22	Aristolochic acid	0.004
5	Unknown (all cancer types)	0
6	Defective DNA MMR / MSI (small INDELs)	0
8	Unknown (breast cancer and medulloblastoma)	0
9	POLH (CLL, BCL)	0
13	APOBEC	0
14	Unknown (uterine cancer and glioma / hypermutation)	0
15	Defective DNA MMR (small INDELs)	0
16	Unknown (liver cancer)	0
18	Unknown (different cancers)	0
19	Unknown (pilocytic astrocytoma)	0
20	Defective DNA MMR (small INDELs)	0
24	Aflatoxin	0
25	Unknown (Hodgkin lymphoma)	0
26	Defective DNA MMR (small INDELs)	0
27	Unknown (kidney clear cell carcinomas / small INDELs)	0
28	Unknown (stomach cancer)	0
29	Tobacco chewing	0
30	Unknown (breast cancer)	0