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. Author manuscript; available in PMC: 2023 Apr 1.
Published in final edited form as: Ann Surg. 2022 Apr 1;275(4):784–792. doi: 10.1097/SLA.0000000000004231

TABLE 2.

Summary of Characteristics of the Recursive Partitioning Analysis (RPA) Groupings After Condensing Into the Fewest Groups Possible

When the Number of Metastatic Sites is... And Biomarker Status is... And the Grade and cT Stage is... Then the Prognostic Stage Group is...
1 Any ER, any PR, HER2+ Any grade, any cT stage IVA
ER+,PR−, HER2− Any grade, any cT stage IVB
ER+,PR+, HER2− Grade 1–2, any cT stage IVA
Grade 3, cT0–3 IVA
Grade 3, cT4 IVB
ER−, any PR, HER2− Any grade, any cT stage IVC
2 ER+, PR+, HER2+ Any grade, any cT stage IVA
ER−, any PR, HER2+ Any grade, any cT stage IVB
ER+,PR−, HER2+ Any grade, any cT stage IVB
ER+,PR+, HER2− Any grade, any cT stage IVB
ER+/PR−/HER2− Any grade, any cT stage IVC
ER−, any PR, HER2− Any grade, any cT stage IVC
≥3 Any ER, any PR, any HER2 Any grade, any cT stage IVC

Analysis based on adults with de novo metastatic breast cancer from the national cancer data base (2010–2013).

ER indicates estrogen receptor; HER2, human epidermal growth factor receptor 2; PR, progesterone receptor.