Table-I.
CTL epitopes in CHIKV-E2 sequences.
| Start Position | Epitope | ANN/SVM Score | Restricting HLA |
|---|---|---|---|
| 1 | STKDNFNVY | 0.98/1.05 | HLA-A*0206, HLA-A3, HLA-B*51,HLA-Cw*0401 |
| 143 | SRPQHGKEL | 0.95/1.02 | HLA-Cw*0401 |
| 371 | VSVA[T/S]FILL | 0.95/0.90 | HLA-B*5102, HLA-B*5103,HLA-Cw*0401 |
| 271 | ARNPTVTYG | 0.88/0.87 | HLA-Cw*0401 |
| 363 | YPTMTVVVV | 0.86/0.84 | HLA-B*5301, HLA-B*51, HLA-Cw*0401 |
| YPTMHVVVV | 0.86/0.54 | HLA-B*51, HLA-Cw*0401 | |
| YPTMTVVIV | 0.86/1.39 | HLA-A*0301, HLA-B*5301, HLA-Cw*0401 | |
| YPTITVVVV | 0.86/0.91 | HLA-B*5301, HLA-B*51, HLA-Cw*0401 | |
| 365 | TMTVVVVSV | 0.68/0.96 | HLA-B*5301, HLA-B*51, HLA-Cw*0401 |
| 276 | VTYGKNQVI | 0.99/0.63 | HLA-A11, HLA-A3, HLA-Cw*0401 |
| 221 | KVDQCHAAV | 0.55/1.07 | HLA-B*51, HLA-Cw*0401 |
| 130 | HHDPPVIGR | 0.95/0.42 | HLA-Cw*0401 |
| 78 | AERAGLFVR | 0.72/0.62 | HLA-Cw*0401 |
| 313 | HKKEVVLTV | 0.82/0.47 | HLA-A*0301, HLA-B*5301, HLA-Cw*0401 |
| 270 | KARNPTVTY | 0.89/0.38 | HLA-A1, HLA-B*51, HLA-Cw*0401 |
| 260 | PLAN[A/V]TC[R/M]V | 0.67/0.51 | HLA-A24, HLA-A*0301, HLA-Cw*0401 |
| 368 | VVVVSVATF | 0.66/0.42 | HLA-Cw*0401 |
| 212 | TTDKVINNC | 0.54/0.52 | HLA-Cw*0401 |
| 385 | AVGMCMCAR | 0.98/0.37 | HLA-Cw*0401 |
| 211 | ITTDKVINN | 0.91/0.39 | HLA-Cw*0401 |
| 373 | VASFILLSM | 0.58/0.39 | HLA-Cw*0401 |
| 159 | STAATTEQI | 0.81/0.42 | HLA-A11, HLA-A3, HLA-A31, HLA-Cw*0401 |
Epitopes specific for s27 and Pakistani isolates are marked red and blue respectively. Epitopes variation are marked with green Epitopes specific for s27 and Pakistani strains are marked red and blue respectively.