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. 2020 Nov 11;14(1):101–117. doi: 10.1007/s40271-020-00462-3

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

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Fig. 5 — Change over time: ANOVA comparison of changes in CCSQ evening scores between day 1 and day 2 for change groups defined by CGI-S changes between day 1 and day 2 (N = 138). ANOVA analysis of variance, CCSQ Child Cold Symptom Questionnaire, CGI-S Child Global Impression of Severity, SEM standard error of the mean. Note, “nasal,” “aches and pain,” and “day nasal” are multi-item scores (made up of 3, 2, and 2 items, respectively) and therefore have possible change score ranges of 0–12, 0–8, and 0–8, respectively, rather than 0–4 as for the other items. *ANOVA showed statistically significant differences among change groups at the P < 0.05 level. **ANOVA showed statistically significant differences among change groups at the P < 0.01 level. ***ANOVA showed statistically significant differences among groups at the P < 0.001 level