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. 2021 Jan 8;11:48. doi: 10.1038/s41598-020-80084-9

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Regional plots of novel pleiotropic loci associated with birthweight and childhood obesity traits. (A) rs6887211 (EBF1) locus association with both birth weight and childhood body mass index (B) rs7958572 (LMRB1L) locus associated with both birthweight and childhood obesity or childhood body mass index. The horizontal axes cover a region 500 kb upstream and downstream from the reference SNP. The vertical axes denote the joint association probabilities of the SNPs with both birthweight and childhood obesity traits. The purple triangles denote the index SNPs (rs6887211 in EBF1 and rs7958572 in LMRB1L). All other colored points denote the surrounding SNPs in that region, and they are colored based on their linkage disequilibrium (r²) with the reference SNP. The box at the bottom shows genes that fall in the region.