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. 2021 Jan 8;11:32. doi: 10.1038/s41598-020-79378-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Proteins are differentially regulated among wounded OCT-treated skin and controls. Abdominal skin biopsies of donors (age range: 38–45 years, n = 5) were TS, treated with OCT, control gel or left untreated, cultivated for 48 h and subsequently prepared for LC–MS analysis. Volcano plots show differences in LFQ values (fold change, logarithmic scale to the base of two) on the x-axis including their corresponding p-values (logarithmic scale) on the y-axis. Proteins marked in red are significantly differentially regulated (Log₂FC < -1 = downregulated; Log₂FC > 1 = upregulated) in OCT treated samples compared to (A) control gel-treated samples or (B) untreated samples. Larger sized dots indicate proteins that are differentially regulated in OCT treated samples compared to both, control gel-treated samples and untreated samples. Registered proteins were further analysed. Data presented in the plots was generated performing a two-sided t-test (p < 0.05) using Perseus and vulcano plots were generated using Graphpad Prism. Extended information on the proteins can be found in Tables S1 and S2.