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. 2021 Jan 8;11:32. doi: 10.1038/s41598-020-79378-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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OCT regulates proteins involved in wound healing and immune response. Full skin biopsies of donors (age range: 38–45 years, n = 5) were TS, treated with OCT, control gel or left untreated, cultivated for 48 h and subsequently prepared for LC–MS analysis. Classification by the GO term biological process shows pathways and larger processes made up of the activities of multiple proteins. Fold enrichment values for individual GO terms, count (proteins involved in the term), p-value and FDR (false discovery rate, calculated using the Benjamini–Hochberg procedure), listed next to the graph, were calculated using DAVID bioinformatics resources. Biological processes downregulated in OCT-treated TS samples are shown in dark grey, processes upregulated in OCT-treated TS samples are shown in light grey.