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. 2021 Jan 8;11:32. doi: 10.1038/s41598-020-79378-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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More proteins are significantly differentially regulated upon OCT treatment in the dermis than in the epidermis. Full skin biopsies of healthy female donors (age range: 36–44 years, n = 3) were TS, treated with OCT, control gel or left untreated and cultivated for 48 h. Subsequently, epidermis was detached from dermis and the two compartments were separately prepared for LC–MS analysis. Volcano plots show differences in LFQ values (fold change, logarithmic scale to the base of two) on the x-axis including their corresponding p-values (logarithmic scale) on the y-axis. Proteins marked in red are significantly differentially regulated (Log₂FC < -1 = downregulated; Log₂FC > 1 = upregulated) in OCT treated TS samples compared to control gel-treated TS samples or untreated TS samples. Data presented in the plots was generated performing a two-sided t-test (p < 0.05) using Perseus and Volcano plots were generated with Graphpad Prism using exclusively proteins with a p-value < 0.01.