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. 2021 Jan 6;10(1):8. doi: 10.1167/tvst.10.1.8

Figure 4.

Figure 4.

Significant RGC and visual function loss can be induced by 3 weeks after initial impact with as few as three repetitive impacts. (A) OKR scores compared by repeated-measures ANOVA over a 21-day time course were significantly decreased in 5×-M mice (n = 5; xxxP < 0.001) and 3×-M mice (n = 4; xP < 0.05) compared with control mice (n = 3). OKR scores were not significantly decreased in 1×-M mice (n = 3). Only 5×-M mice showed decreased OKR scores at any individual time points compared with control mice and as determined by ANOVA (*P < 0.05). (B) Brn3-stained, flat-mounted retinal sections from mice sacrificed on day 21 demonstrated significant RGC loss in 3×-M mice (n = 4; **P < 0.01) and 5×-M mice (n = 5; ***P < 0.001) compared with control mice, but 1×-M mice (n = 3) did not show significant RGC loss. N represents the number of mice; each average of left and right eye is plotted as a single data point. Data represent mean ± SEM.