Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jan 6;10(1):8. doi: 10.1167/tvst.10.1.8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright 2021 The Authors

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

PMC Copyright notice

Figure 5. — RGC and vision loss is bilateral. (A) OKR scores compared by repeated-measures ANOVA over 70 days were significantly decreased in right eyes (OD) (n = 4; ^xxxP < 0.001) and left eyes (OS) (n = 4; ^xxxP < 0.001) of 5×-M mice compared with right and left eyes of control mice (n = 4), respectively. Decreased OKR scores at individual time points, compared with the corresponding eyes of control mice, were determined by ANOVA (^*P < 0.05; ^**P < 0.01; ^***P < 0.001). No significant difference was found between right eyes and left eyes within the 5×-M mice over time nor at any individual time points. (B) Brn3a-stained, flat-mounted retinal sections from mice sacrificed on day 70 showed a significant decrease in number of RGCs in both right eyes (n = 4; ^***P < 0.001) and left eyes (n = 4; ^***P < 0.001) of 5×-M mice compared with corresponding eyes of control mice (n = 4). (C) OKR scores compared by repeated-measures ANOVA over 42 days were significantly decreased in right eyes (n = 4; ^xxxP < 0.001) and left eyes (n = 4; ^xxxP < 0.001) of 5×-M mice compared with right and left eyes of control mice (n = 4), respectively. Decreased OKR scores at individual time points, compared with the corresponding eyes of control mice, were determined by ANOVA (^*P < 0.05; ^**P < 0.01; ^***P < 0.001). No significant difference was found between right eyes and left eyes within the 5×-M mice over time nor at any individual time points. (D) Brn3a-stained, flat-mounted retinal sections from mice sacrificed on day 42 showed a significant decrease in RGC numbers in right eyes (^***P < 0.001) and left eyes (^***P < 0.001) of 5×-M mice compared with corresponding eyes of control mice. N represents the number of left or right eyes, each plotted as a single data point. Data represent mean ± SEM.