Table 3.
Performance comparison of the overall classification for AD versus normal controls (NC)* with feature selection.
| Classification Groups | Accuracy (mean/std) | Precision(PPV) (mean/std) | NPV (mean/std) | Specificity (TNR) (mean/std) | Sensitivity (TPR) (mean/std) | F1-Score (mean/std) |
|---|---|---|---|---|---|---|
| AD group versus 1st normal control group | 0.8216 (0.0136) | 0.8504 (0.0186) | 0.7977 (0.0144) | 0.8623 (0.0200) | 0.7811 (0.0189) | 0.8142 (0.0143) |
| AD group versus 2nd normal control group | 0.8280 (0.0142) | 0.8316 (0.0115) | 0.7883 (0.0191) | 0.8424 (0.0119) | 0.7730 (0.0256) | 0.8010 (0.0167) |
| AD group versus 3rd normal control group | 0.8300 (0.0110) | 0.8561 (0.0121) | 0.8079 (0.0177) | 0.8664 (0.0145) | 0.7934 (0.0250) | 0.8233 (0.0134) |
| AD group versus 4th normal control group | 0.8426 (0.0129) | 0.8432 (0.0105) | 0.8423 (0.0170) | 0.8434 (0.0105) | 0.8418 (0.0193) | 0.8424 (0.0137) |
| AD group versus 5th normal control group | 0.7999 (0.0130) | 0.8172 (0.0100) | 0.7851 (0.0197) | 0.8270 (0.0119) | 0.7730 (0.0276) | 0.7942 (0.0161) |
| Average over five datasets | 0.82442 | 0.8397 | 0.80426 | 0.8483 | 0.79246 | 0.81502 |
*The mean and standard deviation values were extracted from five-fold cross validations.
Bold font represents the most optimal performance for each measurement among five-fold cross validations. Italic font represents the least optimal performance.
Abbreviation: AD = dementia caused by Alzheimer’s disease, NC = normal control, PPV = positive predictive value, NPV = negative predictive value, TNR = true negative rate, TPR = true positive rate.