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. 2021 Jan 8;4:45. doi: 10.1038/s42003-020-01579-9

Fig. 4. AdipoRon could increase insulin sensitivity and exercise endurance in AdipoR-humanized mice on a high-fat diet.

Fig. 4

Body weight (a), food intake (b), plasma glucose (c, e), plasma insulin (d, f) and insulin resistance index (g) during oral glucose tolerance test (OGTT) (1.0 g glucose per kg body weight), exercise endurance (h) in mouse R1·R2DKO mice and muscle-humanR1·Tg/mouse R1·R2DKO (AdipoR1-humanized) mice on a high-fat diet, treated once daily oral administration of AdipoRon (50 mg per kg body weight) for two weeks. All values are presented as means ± s.e.m. *P < 0.05 and **P < 0.01 compared to control mice or as indicated. P values were determined ANOVA followed by Tukey–Kramer multiple comparison tests (a, b, g, h) or unpaired two-tailed t-test (c–f). NS, not significant. R1·R2DKO mice (Vehicle: n = 5; AdipoRon: n = 5), muscle-AdipoR1-humanized mice (Vehicle: n = 3; AdipoRon: n = 3).