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. 2021 Jan 8;11:248. doi: 10.1038/s41598-020-80093-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Positive correlation analysis identifies a network that is enriched in microbial metabolites and is at statistical equilibrium within maternal plasma. Images were generated in Cytoscape (version 3.7.2) using R-Cy3 (version 2.6.3), wherein the network edges represent between-node Spearman’s correlations > 0.90; the distance between nodes indicates strength of interaction. Colors as in Fig. 2; red indicates MDPs, blue indicates endogenous compounds, and green are unknown compounds. The compound X-17010 is likely the MDP 4-vinylcatechol sulfate, based on its molecular mass.