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. 2021 Jan 8;11:248. doi: 10.1038/s41598-020-80093-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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T-Statistic plot of all metabolites present in maternal and fetal tissues, plotted against their − log10 q-values. Metabolites are arranged along x-axis in alphabetical order. The black dashed line indicates the cut-off for the FDR adjusted value of q < 0.05, and the red dashed line indicates q < 0.01. Red dots indicate microbial-derived metabolites having q < 0.05. (a) T-statistic plot of the 854 metabolites detected in maternal liver. (b) T-statistic plot of the 881 metabolites detected in placenta. (c) T-statistic plot of the 854 metabolites detected in fetal liver. (d) T-statistic plot of the 621 metabolites detected in fetal brain. Sample size is n = 9 control and n = 8 alcohol-exposed dams.