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. 2021 Jan 8;11:12. doi: 10.1038/s41598-020-79586-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Interleukin 6 CSF and serum levels following aneurysmal SAH. CSF and blood serum IL-6 levels from day 0 to day 28 are depicted as box plots. The median is marked by the white notch within the quartiles. Outliers are plotted as individual points. IL-6 CSF levels (a) were distinctly higher than serum levels (b) throughout the study period. There was a significant increase over the first few days and the peak median CSF IL-6 value was observed at day 5 after subarachnoid hemorrhage (§ in 1a; day 5 vs. day 1, P < 0.01). No corresponding peak was seen for serum IL-6 levels (# in 1b; day 5 vs. day 1, P = 0.14).