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. 2021 Jan 8;12:155. doi: 10.1038/s41467-020-20466-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a The edge-to-edge distances between NADPH and FAD, FAD and inner heme, and two hemes are shown beside dashes. The ligands are shown as sticks, each domain of hDUOX1 are shown in surface, and colored the same as Fig. 1h. Only one hDUOX subunit is shown for clarity. The putative oxygen-reducing center is boxed by dashed lines. b–e The DH domain of hDUOX1 in a relaxed conformation (b), DH domain of csNOX5 (c), and sFNR (d) in a tense conformation. The ligands are shown as sticks, two subdomains (FAD-binding domain, FBD, and NADPH-binding domain, NBD) of DH are shown as cartoon with surface. Distances between Cα atoms of the Arg (Lys in sFNR) of FBD and the Cys of NBD (shown as spheres) are labeled. e Structural comparison of the hDUOX1 DH domain (cyan) and csNOX5 (purple). FBD is used for structural alignment. f–i The close-up view of the putative oxygen-reducing center. Four predicted tunnels for oxygen substrate entrance and product exit are shown as surface in yellow, green, magenta, and orange, respectively. Residues surrounding the tunnels are shown as sticks. j Calculated radii of tunnels shown in f–i. The putative oxygen-reducing center is used as the starting point for calculation.