Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jan 8;12:155. doi: 10.1038/s41467-020-20466-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 5 — a Structural comparison of hDUOX–hDUOXA1 complex between the high-calcium state (colored) and the low-calcium states (gray). Protein is shown as cartoon. Regions with large conformational changes are boxed by dashed lines. b Close-up view of the conformational changes of EF-hand module. Cα atom of A894 on αJ helix is used as marker to measure the movement of EF2. c Close-up view of the conformational change of PHLD. The angle between αA helices in the high-calcium and low-calcium states was measured. d, e Conformational differences of EF-hand module between the high-calcium state and the low-calcium state. f Reconfiguration of the interface between EF-hand module and α4 helix of DH domain. Arrows denote movements from high-calcium state into the low-calcium state.