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. 2021 Jan 8;10(1):2. doi: 10.1038/s41389-020-00294-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Box-plots showing relative expression levels of TAZ and YAP in 66 primary EwS tumours compared to 89 normal tissues and mesenchymal stem cells (MSC). Affymetrix hgu133a microarray expression data from Kauer et al.⁶¹. b Representative immunoblots showing YAP and TAZ expression under dox-induced EWS-FLI1^low (48 h dox) versus EWS-FLI1^high conditions in different EwS cell lines. c Subcellular localization of TAZ in A673/TR/shEF cells upon EWS-FLI1^high (no dox) and EWS-FLI^low (48 h dox) conditions was analysed by protein fractionation experiments and immunofluorescence microscopy. One representative immunoblot out of three biological replicates is shown. Lamin A/C and α-tubulin were used as nuclear and cytoplasmic fraction controls, respectively. Immunofluorescent pictures are shown at ×40 magnification. d Kaplan–Meier analysis of huex10t microarray expression data for event-free (chi = 4.08, p = 0.043; left graph) and overall (chi = 9.44, p = 2.1e−03; right graph) survival of 85 EwS patients in relation to TAZ expression. Data (GEO ID: gse63157³³) was visualized using the R2 database (http://r2.amc.nl).