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. 2021 Jan 8;12:188. doi: 10.1038/s41467-020-20319-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Structured illumination microscopy images of NLRP1-CARD-mCherry and CARD8-CARD-mCherry filaments (red) with ASC-CARD-GFP and CASP1-CARD-GFP filaments (green). White boxes indicate regions magnified in right panels. b Percentage of ASC-GFP specks or CASP1-CARD-GFP filaments induced by full-length NLRP1 or CARD8 upon Talabostat treatment (3 μM). Data are presented as mean values ± SD. P value was calculated with one-way ANOVA, n = 3 treatments. ‘*/**/****’ indicates P value <0.05, 0.01, and 0.0001, correspondingly. c IL-1β secretion in control, ASC KO, and CASP1 KO keratinocytes transfected with the indicated NLRP1 and CARD8 constructs. Data are presented as mean values ± SD. P value was calculated with one-way ANOVA, n = 3 transfections. ‘*/**/****’ indicates P value <0.05, 0.01, and 0.0001, correspondingly. d The percentage of cells with pyroptotic morphology in control, ASC KO, and CASP1 KO keratinocytes transfected with the indicated NLRP1 and CARD8 constructs. Data are presented as mean values ± SD. P value was calculated with one-way ANOVA, n = 3 transfections (same as 5c). ‘*/**/****’ indicates P value < 0.05, 0.01, and 0.0001, correspondingly.