Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jan 8;11:96. doi: 10.1038/s41598-020-78850-w

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

mHTT aggregates form intranuclear inclusions and get co-localised with p62/SQSTM1 in R6/2 in the striatum at 12 weeks. (A) Representative images for Immunohistochemistry for labelling of mHTT aggregates by EM48, and ATG proteins p62/SQSTM1, LC3B from wild-type and R6/2 mice. p62/SQSTM1 labelled in green, LC3B in red, and mHTT (EM48) in Blue. (B) Representative images for Immunohistochemistry for labelling of mHTT aggregates by EM48, and ATG proteins p62/SQSTM1, and GABARAPL2 from wild-type and R6/2 mice. p62/SQSTM1 labelled in green, GABARAPL2 in red, and mHTT (EM48) in Blue. Magnification = 63X. Scale bar = 5 μm. N = 3. White arrow indicates co-localisation of mHTT (EM48) aggregates with ATG markers. White arrowheads indicate co-localisation of p62/SQSTM1 with GABARAPL2. Yellow arrows indicate co-localisation of mHTT (EM48) aggregates with p62/SQSTM1. N = number of mice.