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. 2021 Jan 8;11:96. doi: 10.1038/s41598-020-78850-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Nilotinib (Tasigna™) does not affect the expression of ATG proteins and clearance of mHTT aggregates at 12 weeks in Striatum in R6/2. (A) Representative images of Immunohistochemistry for labelling ATG proteins p62/SQSTM1, LC3B from WT-Saline and WT-Tasigna treated mice in the striatum at 12 weeks. p62/SQSTM1 labelled in green, LC3B in red. (B) Representative images of Immunohistochemistry for labelling ATG proteins p62/SQSTM1, GABARAPL2 from WT-Saline and WT-Tasigna treated mice in the striatum at 12 weeks. p62/SQSTM1 labelled in green, GABARAPL2 in red. (C) Representative images for Immunohistochemistry for labelling mHTT aggregates by EM48, and ATG proteins p62/SQSTM1 LC3B from R6/2-Saline and R6/2-Tasigna treated mice in the striatum at 12 weeks. mHTT (EM48) aggregates are labelled in Blue, p62/SQSTM1 in green, and LC3B in red. (D) Representative images for Immunohistochemistry for labelling of mHTT aggregates by EM48, and ATG proteins p62/SQSTM1, and GABARAPL2 from R6/2-Saline and R6/2-Tasigna treated mice in the striatum at 12 weeks. mHTT (EM48) aggregates are labelled in Blue, p62/SQSTM1 in green, and GABARAPL2 in red. Magnification = 63X. Scale bar = 5 μm. N = 3 WT-Saline, and WT-Tasigna; N = 3 R6/2-Saline, and R6/2-Tasigna. N = number of mice, White arrowheads indicate co-localisation of p62/SQSTM1 with LC3B or GABARAPL2. White arrow indicates co-localisation of mHTT (EM48) aggregates with ATG markers.