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. 2021 Jan 8;12:144. doi: 10.1038/s41467-020-20418-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Concentration-dependent inhibition of activated Gαq proteins by 1 and 2 as determined by label-free whole-cell DMR biosensing. DMR recordings are representative (mean + s.e.m.) of at least four independent biological replicates conducted in triplicate. b. Competition binding experiments of 1 and 2 versus the FR-derived radiotracer [³H]PSB-15900 at human platelet membrane preparation (50 µg protein per vial), incubated at 37 °C for 1 h. c Exposure of nymphs of a stink bug (Riptortus pedestris) to different concentrations of 1 (left) and 2 (right), survival rate was measured. d Docked poses of 1 (left, represented in sticks and colored in orange, the N-Pp-Hle group present only in 1 is colored in green) and 2 (represented in sticks and colored in blue) in the binding pocket of the Gαq protein shown as line representation. Some of the interactions common for 1 and 2 are indicated by red dotted lines, and the interactions specific for 1 are shown as green dotted lines. Oxygen atoms are colored in red, nitrogen atoms in blue and polar hydrogen atoms in white. e Concentration-dependent inhibition of activated Gαq proteins by 1 and 7 as determined by label-free whole-cell DMR biosensing (see a). Source data are provided as a Source Data file.