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. 2021 Jan 8;11:40. doi: 10.1038/s41598-020-79524-3

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2021

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The structure of FAT1 and its co-IP with GPC3. (A) Schematic diagram of FAT1 structure. (B) Structural model of FAT1 (residues 3662-3788). The model was built on the crystal structure of the human receptor tyrosine phosphatase IA-2 (insulinoma- associated protein 2) (PDB ID# 2QT7), and FAT1 (residues 3662-3778) structure resembled the extracellular domain of IA-2. The 3D structural model was made by using the software SWISS-MODEL (https://swissmodel.expasy.org/). (C) co-IP of endogenous FAT1 by GPC3 in HepG2 cells. GPC3 was pulled down by the hYP7 antibody. The co-IP of FAT1 was detected by anti-FAT1 antibody. Pooled hIgG was used as isotype control of hYP7. The original blots were presented in Supplementary Figure S1.