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. 2021 Jan 8;11:135. doi: 10.1038/s41598-020-79748-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Illustration of accuracy and precision of the estimated dMRI indices of the synthetic DTDs in Fig. 1c with varying fraction of anisotropic components. The upper and lower boundary of the shaded areas illustrate the 25% and 75% percentiles of the estimated indices in simulations. The solid red or blue lines show the mean value of the estimated indices and the corresponding dashed lines show the underlying true values. The SNR of the simulated signals is equal to 30.