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. 2021 Jan 8;4:59. doi: 10.1038/s42003-020-01538-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a The total locomotor activity during the entire 2 h session in a novel environment was enhanced in Grin2a^S/S mice. b Similarly, the exploratory behavior of Grin2a^S/S mice remained high in all three successive 6 min exposure sessions to five novel objects (ITI = 4 min), as exemplified by traces of the animal’s movement on the right. c (left) The time of first fall (Cliff Avoidance Reflex, CAR) was significantly reduced for Grin2a^S/S and Grin2a^+/S mice. c (right) In a 60-min session Grin2a^S/S mice showed a significantly increased number of falls compared to wild-type mice. d (left) In the three-chamber sociability test Grin2a^S/S mutants had a significantly reduced preference to explore the stimulus mouse over the object compared to Grin2a^+/S and Grin2a^+/+ littermates. d (right) Occupancy heat maps in the three-chamber sociability test show a representative example of a Grin2a^S/S mouse with a reduced preference for another mouse versus an inanimate object. The social preference is visible for Grin2a^+/+ and Grin2a^+/S mice. The occupancy is color-coded separately for each group and translates to a % given in white numbers on the key for each genotype. e During the novel object recognition test, Grin2a^S/S mice displayed significantly more interactions with the two objects in both the sample and test runs compared to their Grin2a^+/S and Grin2a^+/+ littermates. During the test run, only the Grin2a^+/S and Grin2a^+/+ showed a significant preference for the novel object over the familiar object. There was no significant novelty preference in the Grin2a^S/S mice. f During the sample run in the Y-maze Grin2a^S/S mice made significantly more total arm entries. In the test run, Grin2a^+/+ and Grins2a^+/S showed a preference for the unexplored novel Y-maze arm, whereas Grin2a^S/S mice showed a lack of novelty preference. The numbers of mice are shown in brackets or below the bars of bar graphs. Chance levels (Ch.) are indicated by dashed lines. Error bars represent mean ± SEM (for statistics: Supplementary Statistics to Fig. 7).