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. 2021 Jan 8;4:61. doi: 10.1038/s42003-020-01584-y

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© The Author(s) 2021, corrected publication 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — a Venn diagram of differentially expressed genes (P < 0.05) in the brain tissue of vehicle-treated and CP2-treated NTG and APP/PS1 mice. Overlapped DEGs (567) represent specific gene pools affected by CP2 treatment. b Heatmap of the overlapped 567 genes shows two clusters where CP2 treatment reversed (upregulated or downregulated) the expression of a subset of genes in APP/PS1 mice to the levels observed in NTG littermates. Gene function enrichment analysis shows pathways associated with downregulated (Cluster 1) or upregulated (Cluster 2) genes after CP2 treatment in APP/PS1 mice. c Pie diagrams showing the number of downregulated (upper graph) and upregulated (lower graph) DEGs in vehicle-treated APP/PS1 mice that correlate with corresponding downregulated or upregulated DEGs in the human AMP-AD dataset, respectively. d Enriched functions of downregulated DEGs in vehicle-treated APP/PS1 mice that correlate with the identified downregulated DEGs in the human AMP-AD dataset. e Enriched functions of upregulated DEGs in vehicle-treated APP/PS1 mice that correlate with the identified upregulated DEGs in the human AMP-AD dataset. All mice were 23-month-old treated with CP2 or vehicle for 13–14 months. NTG, n = 4 mice per group; APP/PS1 and APP/PS1 + CP2, n = 5 mice per group.