Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jan 8;11:246. doi: 10.1038/s41598-020-80725-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

AG1529 affects capsaicin-evoked nociceptor firing. (A) Representative recordings of APs firing from DRG neurones elicited by 0.5 μM capsaicin in the absence (Untreated) and presence (AG1529) of 1 µM AG1529. APs were recorded under current clamp mode. Horizontal lines denote the duration of compound pulse. (B) Ratio of second (P2) versus first (P1) peak of APs evoked by capsaicin application in the absence (n = 12) and the presence during the P2 of 1 µM AG1529 (n = 12). (C) Representative macroscopic ionic currents evoked by a series of depolarizing 5 mV voltage steps of 10 ms, from − 50 mV to 55 mV from a holding potential of − 70 mV, in the absence (black) and the presence (blue) of 1 µM AG1529. (D) and (E) current density to voltage relationships for the inward and outward currents of panel (C), respectively. All data are expressed as mean ± SEM. Data depicted in panel (B) was analysed using an unpaired, two-tail Student’s t-test. p-value is indicated.