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. 2021 Jan 8;11:181. doi: 10.1038/s41598-020-80476-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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GenNLC-Dex-Mox hydrogel dose dependently inhibited SRA cell proliferation and EMT. The results of western blotting (a) and RT-PCR (b) both illustrated decreased expression of α-SMA in lens epithelial cells treated by the GenNLC-Dex-Mox thermoresponsive in situ gel in a dose-dependent manner. (c,d) PCNA and Ki-67 are cell proliferation-associated proteins. The GenNLC-Dex-Mox hydrogel treatment dose-dependently reduced the expression levels of PCNA as well as those of Ki-67. (e) Immunofluorescence illustrated the same trends of decreased expression of α-SMA protein in lens epithelial cells treated by increasing doses of the GenNLC-Dex-Mox thermoresponsive in situ gel. Results are shown as mean ± SD (n = 3). *P < 0.05, **P < 0.01, ***P < 0.001.