Table 1.
Study Participants (Median, Interquartile Range for Continuous Data)
| BMDCS (n = 1837) | CF (n = 65) | ALL (n = 45) | CD (n = 72) | |
|---|---|---|---|---|
| Baseline age, years | 10.9 (6.7,13.6) | 9.9 (8.3, 12.3) p = 0.002 | 7.7 (6.6, 12.4) p = 0.0003 | 14.3 (11.8, 16.3) p < 0.0001 |
| Sex, % female | 50.7 | 44 | 62 | 37 |
| Ancestry, % AA | 16.7 | 0 | 11 | 12 |
| Baseline Wt-Z | 0.39 (−0.25, 0.95) | −0.42 (−0.87, 0.04) p = 0.0001 | 0.92 (0.45, 1.52) p = 0.0001 | −0.39 (−1.27, 0.49) p < 0.0001 |
| Baseline Ht-Z | 0.13 (−0.42, 0.73) | −0.40 (−0.96, 0.08) p = 0.0001 | 0.46 (−0.16–1.14) p = 0.02 | −0.73 (−1.33, −0.028) p = 0.0001 |
| Baseline BMI-Z | 0.37 (−0.26, 0.96) | −0.15 (−0.56, 0.47) p = 0.0001 | 1.05 (0.31, 1.44) p = 0.0001 | −0.04 (−0.82, 0.82) p = 0.001 |
| Baseline LBMI-Z (n = 1418; for age ≥8 years) | −0.15 (−0.68, 0.34) | −0.52 (−0.94, −0.02) p < 0.0001 | −0.26 (−0.80, 0.72) p = 0.9 | −1.03 (−1.91, −0.6) p < 0.0001 |
| Wt-Velocity (kg/year) | 4.1 (2.13, 5.49) | 3.63 (2.03–5.16) | 6.02 (2.87–12.2) | |
| Ht-Velocity (cm/year) | 5.63 (4.98, 6.82) | 5.72 (3.71, 6.54) | 4.77 (1.2–8.12) | |
| Ht-Velocity-Z | 0.09 (−0.53, 0.080) p = 0.6; n = 70 | 0.02 (−0.75, 1.02) p = 0.3; n = 43 | 1.05 (−0.15–1.68) p < 0.0001; n = 66 | |
| Baseline TBLH BMC-Z | 0.04 (−0.50, 0.56) | −0.13 (−0.63, 0.47) p = 0.41; n = 65 | 0.13 (−0.36, 0.72) p = 0.4 | −0.42 (−1.09, 0.24) p = 0.0001 |
| Baseline LS aBMD-Z | 0.03 (−0.59, 0.64) | −0.27 (−0.89, 0.38) p = 0.02; n = 62 | −0.33 (−0.75, 0.32) p = 0.13 | −0.70 (−1.34, 0.04) p = 0.0001 |
| Baseline TotHip aBMD-Z | 0.08 (−0.67, 0.75) | −0.68 (−1.51–0.16) p = 0.0001 | −0.69 (−1.32, −1.21) p = 0.0001 | |
| Baseline FN aBMD-Z | −0.005 (−0.67, 0.71) | −0.38 (−1.21, 0.17) p = 0.003 | −0.81 (−1.59, −0.41) p = 0.0001 | |
| Baseline 1/3-Radius BMD-Z | −0.05 (−0.69, 0.71) | −0.24 (−0.81, 0.51) p = 0.4 |
DXA BMC/aBMD-Z data are height-for-age-Z score adjusted.
AA = African American; aBMD = areal bone mineral density; ALL = acute lymphoblastic leukemia; BMC = bone mineral content; BMDCS = Bone Mineral Density in Childhood Study; BMI = body mass index; CD = Crohn’s disease; CF = cystic fibrosis; FN = femoral neck; HT = height; LBMI = lean body mass index; LS = lumbar spine; TBLH = total body less head; TotHip = total hip; Wt = weight.