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. Author manuscript; available in PMC: 2022 Feb 1.
Published in final edited form as: Physiol Behav. 2020 Dec 5;229:113279. doi: 10.1016/j.physbeh.2020.113279

Figure 4. Conditioned Taste Aversion/Avoidance.

Figure 4.

All rats had 2 pairings of 0.15% saccharin with LiCl. On the test day, rats were treated with either vehicle (Veh; n=7) or 2.4μg/kg Ex-4 (n=7) 15 minutes prior test. Conditioned taste aversion was measured using the Taste Reactivity Test and conditioned taste avoidance was assessed using a Two-bottle Test. Taste Reactivity Test: A. Mean log 10 latency (sec) to 1st passive drip following intraoral delivery of the LiCl-paired saccharin cue in Veh and Ex-4 treated rats. B. Mean log 10 latency (sec) to elicit the 1st gape following the IO infusion of the LiCl-paired saccharin cue in Veh and Ex-4 treated rats. C. Mean number of aversive responses (gapes/15 min) during IO delivery of the LiCl-paired saccharin cue in Veh or Ex-4 treated rats. D. Two-bottle Test. Mean intake (ml/24 h) of water vs. saccharin in rats treated with Veh or Ex-4. Vehicle: white bars, n=7. Ex-4: black bars, n=7.