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. 2021 Jan 5;18(1):333. doi: 10.3390/ijerph18010333

Table 2.

Classification of anaphylaxis severity [14].

Classification by Ring and Messmer
Grade I Generalized skin symptoms (e.g., flush, generalized urticaria, angioedema)
Grade II Mild to moderate pulmonary, cardiovascular, and/or gastrointestinal symptoms
Grade III Anaphylactic shock, loss of consciousness
Grade IV Cardiac arrest, apnea