Skip to main content
. 2021 Jan 2;26(1):195. doi: 10.3390/molecules26010195

Table 2.

The second-order rate constants for oxidation (SS formation) of hirudin CX-397 [19,21].

pH and Additive k1 for R → 1SS
(mM−1 s−1)
k2 for 1SS → 2SS
(mM−1 s−1)
k3 for 2SS → 3SS
(mM−1 s−1)
4.0 4.3 ± 0.2 2.6 ± 0.1 1.2 ± 0.1
7.0 9.8 ± 0.5 6.6 ± 0.3 2.8 ± 0.3
8.0 18.6 ± 1.0 10.0 ± 0.6 3.6 ± 0.6
8.0, +2 M Gdn-HCl 9.8 ± 0.6 5.0 ± 0.3 2.7 ± 0.2