Table 2.
Effect of soy proteins and peptides on lipid metabolism.
| Soy Protein | Peptides | Doses | Experimental Model | Effects/Bioactivity | References |
|---|---|---|---|---|---|
| Glycinin (11S) | IAVPGEVA, IAVPTGVA, LPYP | 25, 50, 100, 150, 200, 250, 300, 400, 500, 650, 1000 µM | HepG2 cell line | Increased LDLR activity Inhibition of HMGCR Activation of the AMPK pathway and ERK1/2 |
[63] |
| IAVPGEVA | - | Microsomes from rat liver | Inhibition of HMGCR Seizure of bile acids |
[64] | |
| β-Conglycinin (7S) | YVVNPDNDEN, YVVNPDNNEN | 350 and 500 μM | HepG2 cell line | Inhibition of HMGCR Upregulation of the mature SREBP-2 protein level Increased the level of LDLR protein |
[68] |
| α, α′ subunits | 0.25, 0.50, 0.75 g/L | HepG2 cells line | Upregulation of the LDLR | [70] | |
| α, α′ and β subunits | 10−4 mol/L | HepG2 cells line | Upregulation of the LDLR | [59] | |
| FVVNATSN | 100 µM | Human hepatocytes (Hep T9A4) | Influenced LDLR transcription | [71] | |
| 2S albumin | Lunasin | - | HepG2 cells line | Reduced expression of HMGCR | [72] |
Abbreviations: AMPK, AMP-activated protein kinase; LDLR, low-density lipoprotein receptor; HMGCR, 3-hydroxy-3-methylglutaryl coenzyme A reductase; ERK1/2, extracellular signal-regulated protein kinases 1 and 2; SREBP-2, Sterol regulatory element-binding protein-2.