Table 2.
Suppressive effects of luteolin treatment on the top 20 altered pathways in high-fat-diet mice.
| Top 20 Canonical Pathways in HFD mice | HFD | ARE | Lut | |
|---|---|---|---|---|
| 1 | Fcγ Receptor-Mediated Phagocytosis in Macrophages and Monocytes | up | up | down |
| 2 | Leukocyte Extravasation Signaling | up | up | down |
| 3 | Phagosome Formation | up | up | down |
| 4 | Granulocyte Adhesion and Diapedesis | up | up | down |
| 5 | Natural Killer Cell Signaling | up | up | down |
| 6 | IL-10 Signaling | up | up | - |
| 7 | Dendritic Cell Maturation | up | up | down |
| 8 | Atherosclerosis Signaling | up | up | down |
| 9 | Production of Nitric Oxide and Reactive Oxygen Species in Macrophages | up | up | down |
| 10 | PI3K Signaling in B Lymphocytes | up | up | - |
| 11 | TREM1 Signaling | up | up | down |
| 12 | Hepatic Fibrosis/Hepatic Stellate Cell Activation | up | up | down |
| 13 | Altered T cell and B cell Signaling in Rheumatoid Arthritis | up | up | down |
| 14 | Agranulocyte Adhesion and Diapedesis | up | up | down |
| 15 | Communication between Innate and Adaptive Immune Cells | up | up | down |
| 16 | CCR5 Signaling in Macrophages | up | up | down |
| 17 | Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses | up | up | down |
| 18 | Toll-like Receptor Signaling | up | up | down |
| 19 | Role of NFAT in Regulation of the Immune Response | up | up | down |
| 20 | B Cell Receptor Signaling | up | up | down |
HFD, high-fat-diet mice; ARE, ARE-Del-/- mice; Lut, HFD with luteolin treatment.