. 2020 Dec 30;22(1):321. doi: 10.3390/ijms22010321

Table 2.

MiRNAs involved in sepsis-induced cardiac dysfunction.

MiRNA	Expression in Sepsis (Myocardium and/or Serum)	Target Genes	Reference
MiR-1-5p	its inhibition is protective	HSPA4	Han et al. 2020 [77]
MiR-7a-5p	`↑`	-	Zhang et al. 2019 [69]
MiR-20b-3p	`↓`	-	Zhang et al. 2019 [69]
MiR-21-3p	`↑` Its up-regulation worsens inflammation	SORBS2	Wang et al. 2016 [47]
MiR-21-5p	`↑` Its up-regulation worsens inflammation	SORBS2	Zhang et al. 2019 [69]
MiR-23b	`↑` its inhibition is protective	TGIF1 PTEN TRAF6 IκκB	Zhang et al. 2018 [61]
MiR-23b	its up-regulation is protective	TGIF1 PTEN TRAF6 IκκB	Cao et al. 2019 [64]
MiR-24	`↑` its inhibition is protective	XIAP	Chen et al. 2020 [73]
MiR-24-1-5p	`↑`	-	Zhang et al. 2019 [69]
MiR-24-2-5p	`↑`	-	Zhang et al. 2019 [69]
MiR-24-3p	`↑`	-	Zhang et al. 2019 [69]
MiR-25	`↓` its up-regulation is protective	PTEN	Yao et al. 2018 [59]
MiR-27a	`↑`	Nrf2	Xue et al. 2015 [37]
MiR-27a-5p	`↑`	-	Zhang et al. 2019 [69]
MiR-29a	`↑` its inhibition is protective	SIRT1	Zhu et al. 2020 [71]
MiR-29a	`↓` its up-regulation is protective		Song et al. 2020 [72]
MiR-30c-5p	`↓`	-	Zhang et al. 2019 [69]
MiR-30d-3p	`↓`	-	Zhang et al. 2019 [69]
MiR-92a-1-5p	`↑`	-	Zhang et al. 2019 [69]
MiR-93-5p	`↓`	-	Zhang et al. 2019 [69]
MiR-93-3p	`↓` its up-regulation is protective	TLR4	Tang et al. 2018 [58]
MiR-98	`↓` its up-regulation is protective	HMGA2	Zhu et al. 2019 [66]
MiR-99a-5p	`↑`	-	Zhang et al. 2019 [69]
MiR-122-5p	`↑`	-	Zhang et al. 2019 [69]
MiR-124a	`↓` its up-regulation is protective	STX2	Diao et al. 2017 [49]
MiR-125b	`↓` its up-regulation is protective	TRAF6	Ma et al. 2016 [43]
MiR-125b	`↓` its up-regulation is protective	TRAF6	Chen et al. 2018 [44]
MiR-126a-3p	`↑`	-	Zhang et al. 2019 [69]
MiR-128-3p	`↑`	-	Zhang et al. 2019 [69]
MiR-132-5p/3p	`↑`	-	Zhang et al. 2019 [69]
MiR-133a-3p/5p	`↓`	-	Zhang et al. 2019 [69]
MiR-135a	`↑` Its up-regulation worsens inflammation	-	Zheng et al. 2017 [50]
MiR-143-3p	`↑`	-	Zhang et al. 2019 [69]
MiR-144-3p	`↓` its up-regulation is protective	-	Wei et al. 2020 [75]
MiR-145-5p	`↓`	-	Zhang et al. 2019 [69]
MiR-146a	`↑` its up-regulation is protective	IRAK1 TRAF6 ErbB4	Gao et al. 2015 [39]
			An et al. 2018 [40]
			Xie et al. 2019 [41]
MiR-146b	`↑` its up-regulation is protective	Notch1	Wang et al. 2018 [42]
MiR-146b-5p/-3p	`↑` its up-regulation is protective		Zhang et al. 2019 [69]
MiR150-5p	`↓` its up-regulation is protective	Akt2	Wei et Liu 2019 [45]
MiR150-5p	`↓` its up-regulation is protective	Akt2	Zhu et al. 2020 [46]
MiR-150-3p	`↓`		Zhang et al. 2019 [69]
MiR-155	`↑` its up-regulation is protective	Pea15a Arrb2	Wang et al. 2016 [48]
MiR-155	`↑` its up-regulation is protective	Pea15a Arrb2	Zhou et al. 2017 [51]
MiR-155-3p	`↑`	-	Zhang et al. 2019 [69]
MiR-181b-1-3p	`↑`	-	Zhang et al. 2019 [69]
MiR-181b-5p	`↓`	-	Zhang et al. 2019 [69]
MiR-192-5p	`↑` its inhibition is protective	XIAP	Sun et al. 2020 [74]
MiR-195-3p	`↑`	-	Zhang et al. 2019 [69]
MiR-200a-5p	`↑`	-	Zhang et al. 2019 [69]
MiR-201-5p	`↓`	-	Zhang et al. 2019 [69]
MiR-208a-5p	`↑` its inhibition is protective	SOCS2	Ouyang et al. 2020 [67]
MiR-210-3p	`↓`	-	Zhang et al. 2019 [69]
MiR-214	`↑` its up-regulation is protective	PTEN	Ge et al. 2018 [52]
MiR-214-3p	`↑` its up-regulation is protective		Sang et al. 2020 [53]
MiR-218a-5p	`↑`	-	Zhang et al. 2019 [69]
MiR-219a-1-3p	`↑`	-	Zhang et al. 2019 [69]
MiR-223-5p	`↓`	Sema3A	Wang et al. 2014 [32]
MiR-233-3p	`↑`	-	Zhang et al. 2019 [69]
MiR-233-5p	`↑`	-	Zhang et al. 2019 [69]
MiR-322-5p	`↓`	-	Zhang et al. 2019 [69]
MiR-328	`↑` its inhibition is protective	-	Sun et al. 2020 [68]
MiR-330-5p	`↑`	-	Zhang et al. 2019 [69]
MiR-330-5p	`↓` its up-regulation is protective	TRAF6	Xing et al. 2020 [74]
MiR-339-3p	`↑`	-	Zhang et al. 2019 [69]
MiR-340-3p	`↑`	-	Zhang et al. 2019 [69]
MiR-362-5p	`↓`	-	Zhang et al. 2019 [69]
MiR-369-5p	`↑`	-	Zhang et al. 2019 [69]
MiR-378a-5p	`↓`	-	Zhang et al. 2019 [69]
MiR-379-5p	`↑`	-	Zhang et al. 2019 [69]
MiR-380-3p	`↑`	-	Zhang et al. 2019 [69]
MiR-409a-3p	`↑`	-	Zhang et al. 2019 [69]
MiR-425-3p	`↓`	-	Zhang et al. 2019 [69]
MiR-434-5p	`↑`	-	Zhang et al. 2019 [69]
MiR-466b-5p	`↑`	-	Zhang et al. 2019 [69]
MiR-490-5p	`↑`	-	Zhang et al. 2019 [69]
MiR-494-3p	`↓` its up-regulation is protective	PTEN	Wu et al. 2018 [60]
MiR-495	`↓` its up-regulation is protective	-	Guo et al. 2019 [65]
MiR-503-5p	`↓`	-	Zhang et al. 2019 [69]
MiR-674-3p	`↑`	-	Zhang et al. 2019 [69]
MiR-708-3p	`↑`	-	Zhang et al. 2019 [69]
MiR-708-5p	`↓`	-	Zhang et al. 2019 [69]
MiR-874	`↑` its inhibition is protective	AQP1	Fang et al. 2018 [54]
MiR-3557-3p	`↓`	-	Zhang et al. 2019 [69]