Table 1.
Clinical characteristics of the TCGA LSCC cohort by primary subsite of cancer.
| Variables | HPV Negative Samples, No. (%) (n = 95) | |||
|---|---|---|---|---|
| Glottis (n = 46) | Supraglottis (n = 49) | p Value 1 | ||
| Age | Median (range) | 61.5 (47–80) | 62 (38–83) | 0.783 |
| Sex | Female | 6 (13) | 13 (27) | 0.13 |
| Male | 40 (87) | 36 (73) | ||
| Smoking history | Nonsmoker | 4 (11) | 1 (3) | 0.17 |
| Light smoker | 4 (11) | 2 (5) | ||
| Heavy smoker | 27 (77) | 36 (92) | ||
| T-category | T1 | 1 (2) | 4 (9) | <10−4 |
| T2 | 5 (11) | 5 (11) | ||
| T3 | 4 (9) | 17 (36) | ||
| T4 | 34 (74) | 12 (26) | ||
| TX | 2 (4) | 9 (19) | ||
| N-category | N0 | 23 (50) | 15 (32) | 0.084 |
| N1 | 7 (15) | 5 (11) | ||
| N2 | 9 (20) | 16 (34) | ||
| N3 | 2 (4) | 0 (0) | ||
| NX | 5 (11) | 11 (23) | ||
| Overall stage | I | 1 (2) | 1 (3) | 0.25 |
| II | 3 (7) | 5 (14) | ||
| III | 4 (9) | 8 (22) | ||
| IV | 36 (82) | 23 (62) | ||
| Adjuvant radiotherapy | no | 11 (31) | 11 (26) | 0.62 |
| yes | 24 (69) | 32 (74) | ||
| Cartilage invasion | no | 8 (21) | 30 (79) | <10−6 |
| yes | 31 (79) | 8 (21) | ||
1 Bolded p values are significant.