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In vitro cytotoxicity of the conjugates.
| Cell Line | IC50 (nM) | ||||
|---|---|---|---|---|---|
| ZHER2:2891-ABD-E3-mcDM1 | ZHER2:2891-ABD-G3-mcDM1 | (ZHER2:2891)2-ABD-E3-mcDM1 | ZHER2:2891-ABD-E3-AA | ZTaq-ABD-mcDM1 | |
| AU565 | 1.11 | 1.31 | 0.65 | ND a | ND |
| SKBR3 | 0.64 | 0.69 | 0.22 | ND | ND |
| SKOV3 | 32.9 | 23.5 | 245 | ND | 619 |
a Not determined.
