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Structural domains of our main FMC63 anti-CD19 CARs. The structural design of the (a) 8-8-41BB CARs, (b) 28-28-28 CARs, (c) 28-28-41BB CARs and (d) IgG4-28-41BB CARs reviewed here. The individual scFv, hinge, transmembrane domain, costimulatory domain and signalling tails are labelled. Horizontal lines between hinge domains indicate disulfide bonds.
