Figure 3.

CAR domain structure influences CRS severity in patients treated with CD19 CAR-T cell therapies. Both CAR type, based on hinge (H), transmembrane (TM) and costimulatory (Costim) domain composition, and CRS grade, separated into none, grade 1–2 and grade 3+, are represented on the left and right y axis, respectively. Each circle represents the percentage of patients in a single clinical trial listed in Table 1 that developed the corresponding grade of CRS (none, grade 1–2 and grade 3+). Middle line represents the mean percentage of patients with the corresponding grade of CRS and error bars represent the SEM (Table S2).